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Rat Abcb7 cDNA Clone(NM_212518.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR015240

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Gene Information

Cat. No. CDFR015240
Description NativeORF clone of Rattus norvegicus ATP-binding cassette, sub-family B (MDR/TAP), member 7 (Abcb7), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_212518.1
Product Type cDAN Clone
Gene Abbr Abcb7
Species Rat
Vector pCMV6Entry
Target Gene ABCB7
Background The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
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