Panoply™ Human TLE1 Knockdown Stable Cell Line

Name: Panoply™ Human TLE1 Knockdown Stable Cell Line
SKU: CSC-DC015988
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC015988

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC015988
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	TLE1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) [ Homo sapiens ]
Gene Symbol	TLE1
Synonyms	ESG; ESG1; GRG1
Gene Description	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
GeneID	7088
Uni ProtID	Q04724
mRNA Refseq	NM_005077.3
Protein Refseq	NP_005068.2
Chromosome Location	9q21.32
Function	RNA polymerase II transcription corepressor activity; chromatin binding; protein binding; transcription factor binding; transcription factor binding;
Pathway	Delta-Notch Signaling Pathway, organism-specific biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Presenilin action in Notch and Wnt signaling, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem;
MIM	600189

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