Panoply™ Human SMAD7 Knockdown Stable Cell Line

Name: Panoply™ Human SMAD7 Knockdown Stable Cell Line
SKU: CSC-DC014717
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC014717

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC014717
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	SMAD7
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SMAD7 SMAD family member 7 [ Homo sapiens ]
Gene Symbol	SMAD7
Synonyms	CRCS3; MADH7; MADH8
Gene ID	4092
Uni Prot ID	O15105
m RNA Refseq	NM_001190821.1
Protein Refseq	NP_001177750.1
Chromosome Location	18q21.1
Function	I-SMAD binding; activin binding; beta-catenin binding; collagen binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding;
Pathway	ALK1 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Downregulation of TGF-beta receptor signaling, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
MIM	602932

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