Panoply™ Human ERCC4 Knockdown Stable Cell Line

Name: Panoply™ Human ERCC4 Knockdown Stable Cell Line
SKU: CSC-DC005036
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC005036

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC005036
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	ERCC4
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4 [ Homo sapiens ]
Gene Symbol	ERCC4
Synonyms	XPF; RAD1; ERCC11
Gene Description	excision repair cross-complementing rodent repair deficiency, complementation group 4
Gene ID	2072
Uni Prot ID	Q92889
m RNA Refseq	NM_005236.2
Protein Refseq	NP_005227.1
Chromosome Location	16p13.12
Function	damaged DNA binding; endodeoxyribonuclease activity; contributes_to endodeoxyribonuclease activity; protein C-terminus binding; protein N-terminus binding; protein binding; single-stranded DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; contributes_to structure-specific DNA binding;
Pathway	DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Formation of incision complex in GG-NER, organism-specific biosystem; Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem;
MIM	133520

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