Panoply™ Human DICER1 Knockdown Stable Cell Line

Name: Panoply™ Human DICER1 Knockdown Stable Cell Line
SKU: CSC-DC004304
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC004304

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-DC004304
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	DICER1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	DICER1 dicer 1, ribonuclease type III [ Homo sapiens ]
Gene Symbol	DICER1
Synonyms	DCR1; MNG1; Dicer; HERNA
Gene Description	Dicer1, Dcr-1 homolog (Drosophila)
Gene ID	23405
Uni Prot ID	Q9UPY3
m RNA Refseq	NM_030621.3
Protein Refseq	NP_085124.2
Chromosome Location	14q32.13
Function	ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; metal ion binding; miRNA binding; protein binding; ribonuclease III activity;
Pathway	Gene Expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystem; mRNA processing, organism-specific biosystem;
MIM	606241

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Q & A

Customer Reviews

Customer Q&As

What is DICER1 syndrome?

A: DICER1 syndrome, first reported in 1996, is a rare genetically inherited disease in which mutations in the DICER1 gene predispose the body to a variety of benign and malignant tumours

What are the clinical symptoms of DICER1 syndrome?

A: mainly multinodular goitre, pleuropneumoblastoma, cystic nephroma, Sertoli-Leydig cell tumour of the ovary, ciliary body medullary epithelioma, embryonal rhabdomyosarcoma of the uterine cervix, differentiated thyroid cancer, etc.

What is the pathogenesis of DICER1?

A: The pathogenesis is due to mutations in the DICER1 gene, which encodes a ribonucleic acid endonuclease, resulting in impaired synthesis and expression of microRNAs and the induction of tumours.

What is the genetic basis of DICER1 syndrome?

A: DICER1 syndrome is an autosomal dominant disorder in which a single mutation in one copy of the gene is sufficient to increase the risk of tumour development. Researchers reported in 2009 that DICER1 syndrome is caused by a mutation in the DICER1 gene. This is also a disease in which mutations in a gene associated with microRNA maturation cause tumours in humans.

Where is the DICER1 gene located on the gene?

A: The DICER1 gene, located on chromosome 14 at q32.13, encodes the DICER protein, a ribonucleic acid endonuclease in the RNA III family, which is directly involved in the regulation of the RNA interference (RNAi) pathway

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