Cat.No. : CSC-DC004304
Host Cell: HEK293 (Hela and other cell types are also available) Validation: Real-Time RCR
| Cat. No. | CSC-DC004304 |
| Description | Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free. |
| Gene | DICER1 |
| Host Cell | HEK293 (Hela and other cell types are also available) |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Application | (1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Size Form | >1 × 10^6 cells / vial |
| Shipping | Dry Ice |
| Storage | Liquid Nitrogen |
| Gene Name | DICER1 dicer 1, ribonuclease type III [ Homo sapiens ] |
| Gene Symbol | DICER1 |
| Synonyms | DCR1; MNG1; Dicer; HERNA |
| Gene Description | Dicer1, Dcr-1 homolog (Drosophila) |
| Gene ID | 23405 |
| UniProt ID | Q9UPY3 |
| mRNA Refseq | NM_030621.3 |
| Protein Refseq | NP_085124.2 |
| Chromosome Location | 14q32.13 |
| Function | ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; metal ion binding; miRNA binding; protein binding; ribonuclease III activity; |
| Pathway | Gene Expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystem; mRNA processing, organism-specific biosystem; |
| MIM | 606241 |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: DICER1 syndrome, first reported in 1996, is a rare genetically inherited disease in which mutations in the DICER1 gene predispose the body to a variety of benign and malignant tumours
A: mainly multinodular goitre, pleuropneumoblastoma, cystic nephroma, Sertoli-Leydig cell tumour of the ovary, ciliary body medullary epithelioma, embryonal rhabdomyosarcoma of the uterine cervix, differentiated thyroid cancer, etc.
A: The pathogenesis is due to mutations in the DICER1 gene, which encodes a ribonucleic acid endonuclease, resulting in impaired synthesis and expression of microRNAs and the induction of tumours.
A: DICER1 syndrome is an autosomal dominant disorder in which a single mutation in one copy of the gene is sufficient to increase the risk of tumour development. Researchers reported in 2009 that DICER1 syndrome is caused by a mutation in the DICER1 gene. This is also a disease in which mutations in a gene associated with microRNA maturation cause tumours in humans.
A: The DICER1 gene, located on chromosome 14 at q32.13, encodes the DICER protein, a ribonucleic acid endonuclease in the RNA III family, which is directly involved in the regulation of the RNA interference (RNAi) pathway
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.
Our promise to you:
Guaranteed product quality, expert customer support.
24x7 CUSTOMER SERVICE
CONTACT US TO ORDER
Copyright © Creative Biogene. All rights reserved.
