Panoply™ Human CREBBP Knockdown Stable Cell Line

Name: Panoply™ Human CREBBP Knockdown Stable Cell Line
SKU: CSC-DC003626
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC003626

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC003626
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	CREBBP
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CREBBP CREB binding protein [ Homo sapiens ]
Gene Symbol	CREBBP
Synonyms	CBP; RSTS; KAT3A
Gene Description	CREB binding protein (Rubinstein-Taybi syndrome)
GeneID	1387
Uni ProtID	Q4LE28
mRNA Refseq	NM_004380.2
Protein Refseq	NP_004371.2
Chromosome Location	16p13.3
Function	MRF binding; RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription coactivator activity; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; acetyltransferase activity; core promoter proximal region sequence-specific DNA binding; histone acetyltransferase activity; p53 binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription coactivator activity; contributes_to transcription coactivator activity; transcription coactivator activity; transcription factor binding; zinc ion binding;
Pathway	Activation of Gene Expression by SREBP (SREBF), organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Angiogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem;
MIM	600140

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