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CREBBP


Official Full Name
CREB binding protein
Organism
Homo sapiens
Gene ID
1387
Background
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Synonyms
CBP; RSTS; KAT3A; MKHK1; RSTS1

Cat.No. Product Name Price
LV00066Z Human CREBBP lentiviral particles Inquiry
Cat.No. Product Name Price
SHH269373 shRNA set against Mouse CREBBP (NM_001025432.1) Inquiry
SHH269377 shRNA set against Rat CREBBP (NM_133381.3) Inquiry
SHG198253 shRNA set against Mouse Crebbp(NM_001025432.1) Inquiry
SHG198271 shRNA set against Human CREBBP(NM_004380.2) Inquiry
SHG198289 shRNA set against Human CREBBP(NM_001079846.1) Inquiry
SHH269369 shRNA set against Human CREBBP (NM_004380.2) Inquiry
Cat.No. Product Name Price
CDCH384115 Human CREBBP ORF clone(NM_004380.2) Inquiry
CDFG014541 Mouse Crebbp cDNA Clone(NM_001025432.1) Inquiry
CDFH004233 Human CREBBP cDNA Clone(NM_001079846.1) Inquiry
CDFR013999 Rat Crebbp cDNA Clone(NM_133381.3) Inquiry
MiUTR1H-02416 CREBBP miRNA 3'UTR clone Inquiry
MiUTR1H-02417 CREBBP miRNA 3'UTR clone Inquiry
MiUTR1M-03316 CREBBP miRNA 3'UTR clone Inquiry
SKO0408 CREBBP Validated sgRNA vector Inquiry
CDCB193257 Rabbit CREBBP ORF clone (XM_008249593.1) Inquiry
CDCH384117 Rat CREBBP ORF clone(NM_133381.3) Inquiry
CDCR042020 Mouse Crebbp ORF clone (NM_001025432.1) Inquiry
CDCR345456 Human CREBBP ORF Clone(NM_001079846.1) Inquiry
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