Mouse Ugt1a1 cDNA Clone(NM_201645.2)

Name: Mouse Ugt1a1 cDNA Clone(NM_201645.2)
SKU: CDFL014655
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL014655

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Product Information

Gene Information

Cat. No.	CDFL014655
Product Type	cDNA clone
Gene Abbr	Ugt1a1
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

UGT1A1

Background

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]

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