Mouse Tiam1 cDNA Clone(NM_001145886.1)

Name: Mouse Tiam1 cDNA Clone(NM_001145886.1)
SKU: CDFG019769
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG019769

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Product Information

Gene Information

Cat. No.	CDFG019769
Product Type	cDNA clone
Gene Abbr	Tiam1
Species	Mouse
ORF Size	4776bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

TIAM1

Background

This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]

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