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Mouse Spg20 cDNA Clone(NM_001144987.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG019712

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Gene Information

Cat. No. CDFG019712
Product Type cDNA clone
Gene Abbr Spg20
Species Mouse
ORF Size 2016bp
Size 10 ug
Vector pCMV6Entry
Target Gene SPG20
Background This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]
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