Mouse Socs2 cDNA Clone(BC106153)

Name: Mouse Socs2 cDNA Clone(BC106153)
SKU: CDFG022025
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG022025

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Product Information

Gene Information

Cat. No.	CDFG022025
Product Type	cDNA clone
Gene Abbr	Socs2
Species	Mouse
ORF Size	597bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

SOCS2

Background

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

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