Mouse Rpgr ORF clone (NM_001177950.1)

Name: Mouse Rpgr ORF clone (NM_001177950.1)
SKU: CDCH075066
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH075066

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Product Information

Gene Information

Cat. No.	CDCH075066
Description	Mus musculus retinitis pigmentosa GTPase regulator (Rpgr), transcript variant 1, mRNA.
Product Type	ORF clone
Gene Abbr	Rpgr
Species	Mouse
ORF Size	3120bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

RPGR

Background

This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008]

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