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Mouse Rfx6 cDNA Clone(NM_001159389.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG019849

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Gene Information

Cat. No. CDFG019849
Product Type cDNA clone
Gene Abbr Rfx6
Species Mouse
ORF Size 2784bp
Size 10 ug
Vector pCMV6Entry
Target Gene RFX6
Background The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]
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