Mouse Rasgrp4 cDNA Clone(NM_145149.4)

Name: Mouse Rasgrp4 cDNA Clone(NM_145149.4)
SKU: CDFL011281
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL011281

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Product Information

Gene Information

Cat. No.	CDFL011281
Product Type	cDNA clone
Gene Abbr	Rasgrp4
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

RASGRP4

Background

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

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