Mouse Ptk2b cDNA Clone(NM_001162365.1)

Name: Mouse Ptk2b cDNA Clone(NM_001162365.1)
SKU: CDFG020115
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG020115

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Product Information

Gene Information

Cat. No.	CDFG020115
Product Type	cDNA clone
Gene Abbr	Ptk2b
Species	Mouse
ORF Size	3018bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

PTK2B

Background

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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