Mouse Plekhm2 cDNA Clone(NM_001033150.1)

Name: Mouse Plekhm2 cDNA Clone(NM_001033150.1)
SKU: CDFG017658
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG017658

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Product Information

Gene Information

Cat. No.	CDFG017658
Product Type	cDNA clone
Gene Abbr	Plekhm2
Species	Mouse
ORF Size	3102bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

PLEKHM2

Background

This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]

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