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Mouse Pgap3 cDNA Clone(NM_001033537.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG017896

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Gene Information

Cat. No. CDFG017896
Product Type cDNA clone
Gene Abbr Pgap3
Species Mouse
ORF Size 963bp
Size 10 ug
Target Gene PGAP3
Background This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
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