Mouse Pcdhgb4 cDNA Clone(NM_033576.1)

Name: Mouse Pcdhgb4 cDNA Clone(NM_033576.1)
SKU: CDFL009997
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL009997

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Product Information

Gene Information

Cat. No.	CDFL009997
Product Type	cDNA clone
Gene Abbr	Pcdhgb4
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

PCDHGB4

Background

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

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