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Mouse Nsmce2 cDNA Clone(NM_001164604.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG020680

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Product Information

Gene Information

Cat. No. CDFG020680
Product Type cDNA clone
Gene Abbr Nsmce2
Species Mouse
ORF Size 420bp
Size 10 ug
Vector pCMV6Entry
Target Gene NSMCE2
Background This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
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