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Mouse Nrxn1 cDNA Clone(NM_020252.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFL008575

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Product Information

Gene Information

Cat. No. CDFL008575
Product Type cDNA clone
Gene Abbr Nrxn1
Species Mouse
Size 10 ug
Vector pCMV6Entry
Target Gene NRXN1
Background This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
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