Mouse Mbd5 cDNA Clone(NM_029924.2)

Name: Mouse Mbd5 cDNA Clone(NM_029924.2)
SKU: CDFL007427
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL007427

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Product Information

Gene Information

Cat. No.	CDFL007427
Product Type	cDNA clone
Gene Abbr	Mbd5
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

MBD5

Background

This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Jul 2017]

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