Mouse Maml2 cDNA Clone(NM_001013813.3)

Name: Mouse Maml2 cDNA Clone(NM_001013813.3)
SKU: CDFG017333
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG017333

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Product Information

Gene Information

Cat. No.	CDFG017333
Product Type	cDNA clone
Gene Abbr	Maml2
Species	Mouse
ORF Size	3513bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

MAML2

Background

The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]

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