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Mouse Loxhd1 ORF Clone(NM_172834.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR271739

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Product Information

Gene Information

Cat. No. CDCR271739
Product Type ORF Clone
Gene Abbr Loxhd1
Species Mouse
Tag C-terminal TurboGFP
ORF Size 6207 bp
Vector pCMV6-AC-GFP
Target Gene LOXHD1
Background This gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins to the plasma membrane. Studies in mice show that this gene is expressed in the mechanosensory hair cells in the inner ear, and mutations in this gene lead to auditory defects, indicating that this gene is essential for normal hair cell function. Screening of human families segregating deafness identified a mutation in this gene which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL). Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
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