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Mouse Klhl3 cDNA Clone(NM_001195075.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG021662

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Gene Information

Cat. No. CDFG021662
Product Type cDNA clone
Gene Abbr Klhl3
Species Mouse
ORF Size 1923bp
Size 10 ug
Vector pCMV6Entry
Target Gene KLHL3
Background This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
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