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Mouse Hspa5 ORF Clone(NM_001163434.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR239775

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Gene Information

Cat. No. CDCR239775
Product Type ORF Clone
Gene Abbr Hspa5
Species Mouse
Tag C-terminal Myc-DDK
ORF Size 1967 bp
Size 10 ug
Vector pCMV6-Entry
Target Gene HSPA5
Background The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
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