Mouse Grm2 ORF clone (NM_001160353.1)

Name: Mouse Grm2 ORF clone (NM_001160353.1)
SKU: CDCL114849
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL114849

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Product Information

Gene Information

Cat. No.	CDCL114849
Description	Mus musculus glutamate receptor, metabotropic 2 (Grm2), mRNA.
Product Type	ORF clone
Gene Abbr	Grm2
Species	Mouse
ORF Size	2619bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

GRM2

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

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