Mouse Fip1l1 cDNA Clone(NM_001159573.1)

Name: Mouse Fip1l1 cDNA Clone(NM_001159573.1)
SKU: CDFG019905
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG019905

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Product Information

Gene Information

Cat. No.	CDFG019905
Product Type	cDNA clone
Gene Abbr	Fip1l1
Species	Mouse
ORF Size	1746bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

FIP1L1

Background

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

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