Mouse FPGS ORF clone (NM_001018078.1)

Name: Mouse FPGS ORF clone (NM_001018078.1)
SKU: CDCL109405
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL109405

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Product Information

Gene Information

Cat. No.	CDCL109405
Description	Homo sapiens folylpolyglutamate synthase (FPGS), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
Product Type	ORF clone
Gene Abbr	FPGS
Species	Human
ORF Size	1614bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

FPGS

Background

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

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