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Mouse F8 ORF Clone(NM_001161374.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR239063

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Product Information

Gene Information

Cat. No. CDCR239063
Product Type ORF Clone
Gene Abbr F8
Species Mouse
Tag C-terminal TurboGFP
ORF Size 6744 bp
Size 10 ug
Vector pCMV6-AC-GFP
Target Gene F8
Background This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
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