Mouse F13a1 ORF Clone(NM_028784.3)

Name: Mouse F13a1 ORF Clone(NM_028784.3)
SKU: CDCR261844
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR261844

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Product Information

Gene Information

Cat. No.	CDCR261844
Product Type	ORF Clone
Gene Abbr	F13a1
Species	Mouse
Tag	C-terminal TurboGFP
ORF Size	2199 bp
Vector	pCMV6-AC-GFP

Target Gene

F13A1

Background

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

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