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Mouse Dennd1b cDNA Clone(NM_001166501.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG020473

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Gene Information

Cat. No. CDFG020473
Product Type cDNA clone
Gene Abbr Dennd1b
Species Mouse
ORF Size 2301bp
Size 10 ug
Vector pCMV6Entry
Target Gene DENND1B
Background Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
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