Mouse Cldn14 ORF Clone(NM_001165926.1)

Name: Mouse Cldn14 ORF Clone(NM_001165926.1)
SKU: CDCR240875
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR240875

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Product Information

Gene Information

Cat. No.	CDCR240875
Product Type	ORF Clone
Gene Abbr	Cldn14
Species	Mouse
Tag	C-terminal TurboGFP
ORF Size	720 bp
Size	10 ug
Vector	pCMV6-AC-GFP

Target Gene

CLDN14

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

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