Mouse Clcn3 cDNA Clone(NM_173874.1)

Name: Mouse Clcn3 cDNA Clone(NM_173874.1)
SKU: CDFL002769
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL002769

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Product Information

Gene Information

Cat. No.	CDFL002769
Product Type	cDNA clone
Gene Abbr	Clcn3
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

CLCN3

Background

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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