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Mouse CXCR2 ORF clone(NM_009909.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL183853

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Product Information

Gene Information

Cat. No. CDCL183853
Description ORF Clone of Mus musculus chemokine (C-X-C motif) receptor DNA.
Product Type ORF clone
Gene Abbr CXCR2
Species Mouse
ORF Size 1080bp
Vector pGEM-T
Warning This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage store at -20°C
Target Gene CXCR2
Background The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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