Mouse CD8B ORF clone(NM_009858.2)

Name: Mouse CD8B ORF clone(NM_009858.2)
SKU: CDCL183439
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL183439

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Product Information

Gene Information

Cat. No.	CDCL183439
Description	ORF Clone of Mus musculus CD8 antigen, beta chain 1 DNA.
Product Type	ORF clone
Gene Abbr	CD8B
Species	Mouse
ORF Size	642bp
Vector	pMD18-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

CD8B

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

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