Mouse Bbs10 cDNA Clone(NM_027914.1)

Name: Mouse Bbs10 cDNA Clone(NM_027914.1)
SKU: CDFL001762
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFL001762

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Product Information

Gene Information

Cat. No.	CDFL001762
Product Type	cDNA clone
Gene Abbr	Bbs10
Species	Mouse
Size	10 ug
Vector	pCMV6Entry

Target Gene

BBS10

Background

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010]

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