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Mouse Asxl3 cDNA Clone(NM_001167777.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG021023

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Gene Information

Cat. No. CDFG021023
Product Type cDNA clone
Gene Abbr Asxl3
Species Mouse
ORF Size 6615bp
Size 10 ug
Vector pCMV6Entry
Target Gene ASXL3
Background This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017]
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