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Mouse Ano3 cDNA Clone(NM_001128103.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG019432

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Gene Information

Cat. No. CDFG019432
Product Type cDNA clone
Gene Abbr Ano3
Species Mouse
ORF Size 2946bp
Size 10 ug
Vector pCMV6Entry
Target Gene ANO3
Background The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
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