Mouse Add3 cDNA Clone(NM_001164101.1)

Name: Mouse Add3 cDNA Clone(NM_001164101.1)
SKU: CDFG020562
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG020562

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Product Information

Gene Information

Cat. No.	CDFG020562
Product Type	cDNA clone
Gene Abbr	Add3
Species	Mouse
ORF Size	2025bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

ADD3

Background

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

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