MBIP adenovirus

The MBIP (MAP3K12-binding inhibitory protein) gene encodes a regulatory protein that plays a key role in cell signaling pathways, particularly in regulating the MAPK (mitogen-activated protein kinase) cascade. This gene is involved in processes such as cell proliferation, differentiation, and stress response, making it a key target for research into diseases such as cancer and inflammation. MBIP, as an inhibitory scaffold protein, binds to MAP3K12 (also known as DLK) and inhibits its kinase activity, thereby affecting downstream signaling events. Dysregulation of MBIP has been associated with tumor progression and neurodegenerative diseases. Due to its regulatory functions, MBIP has attracted significant attention in both basic research and therapeutic development.

The MBIP adenovirus is a recombinant adenoviral vector designed to deliver the MBIP gene to target cells for functional studies or therapeutic applications. Adenoviral vectors are widely used in gene therapy and molecular biology due to their high transduction efficiency, broad tropism, and ability to express transgenes in both dividing and non-dividing cells. The MBIP adenovirus allows researchers to overexpress MBIP in vitro or in vivo, facilitating the study of its role in signaling pathways, cell survival, and disease mechanisms. Furthermore, this vector can be used in gene therapy strategies to restore MBIP function in pathological conditions where its expression is impaired.