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Human XPC Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0015
Background
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
XPC
Synonyms
XPC; xeroderma pigmentosum, complementation group C; DNA repair protein complementing XP-C cells; RAD4; xeroderma pigmentosum group C protein; XPCC; p125; mutant xeroderma pigmentosum group C; XP3;
Gene ID
MIM
UniProt ID
Q01831
Chromosome Location
3p25
Pathway
DNA Damage Recognition in GG-NER, organism-specific biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Formation of incision complex in GG-NER, organism-specific biosystem; Global Genomic NER (GG-NER), organism-specific biosystem; Nucleotide Excision Repair, organism-specific biosystem; Nucleotide excision repair, organism-specific biosystem;
Function
bubble DNA binding; damaged DNA binding; loop DNA binding; protein binding; single-stranded DNA binding;

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