Human VIMP ORF Clone(NM_018445.4)

Name: Human VIMP ORF Clone(NM_018445.4)
SKU: CDCR303780
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR303780

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Product Information

Gene Information

Cat. No.	CDCR303780
Product Type	ORF Clone
Gene Abbr	VIMP
Species	Human
Tag	C-terminal Myc-DDK
ORF Size	570 bp
Vector	pCMV6-Entry

Target Gene

VIMP

Background

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]

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