Human STK4 adenoviral particles

The STK4 gene, also known as mammalian sterile 20-like kinase 1 (MST1), encodes a serine/threonine kinase that plays a key role in cell proliferation, apoptosis, and immune regulation. As a core component of the Hippo signaling pathway, STK4 is essential for maintaining tissue homeostasis and organ size by controlling cell growth and death. It phosphorylates downstream effectors such as LATS1/2, which in turn regulate the transcriptional coactivators YAP/TAZ. STK4 dysregulation has been implicated in a variety of diseases, including cancer, autoimmune disorders, and cardiovascular disease, highlighting its importance in cellular and physiological processes.

Human STK4 adenoviral particles are genetically engineered viral vectors designed to efficiently deliver the STK4 gene to target cells. These particles exploit the natural infectivity of adenoviruses to achieve high transduction rates in both dividing and non-dividing cells, making them ideal for research applications. The adenoviral backbone has been modified to remove viral replication genes for safety while retaining the ability to express STK4 under a strong promoter. These particles are widely used in functional studies to investigate the role of STK4 in signaling pathways, cancer biology, and immune responses.