Human SIGMAR1 ORF clone (NM_147157.1)

Name: Human SIGMAR1 ORF clone (NM_147157.1)
SKU: CDCL149942
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL149942

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Product Information

Gene Information

Cat. No.	CDCL149942
Description	Homo sapiens sigma non-opioid intracellular receptor 1 (SIGMAR1), transcript variant 2, mRNA.
Product Type	ORF clone
Gene Abbr	SIGMAR1
Species	Human
ORF Size	579bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

SIGMAR1

Background

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

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