Human S100A8 adenoviral particles

S100A8, also known as calgranulin A or myeloid-related protein 8 (MRP8), is a member of the S100 calcium-binding protein family. It is encoded by the S100A8 gene located on human chromosome 1. S100A8 normally forms a heterodimer with S100A9, and this complex plays a key role in inflammation and immune responses. S100A8 is highly expressed in the early differentiation stages of neutrophils, monocytes, and macrophages, and is involved in regulating cellular processes such as cell chemotaxis, apoptosis, and immune cell activation. Elevated levels of S100A8 are associated with a variety of pathological conditions, including chronic inflammation, autoimmune diseases, and cancer. Due to its regulatory functions in immunity and disease, S100A8 has become a popular target for therapeutic and research applications. Human S100A8 adenoviral particles are recombinant adenoviral vectors designed to deliver and express the S100A8 gene in mammalian cells. Adenoviral vectors are widely used in gene therapy and molecular research due to their high transduction efficiency, broad tropism, and ability to infect both dividing and non-dividing cells. These particles are genetically engineered to carry the human S100A8 gene under the control of an appropriate promoter, allowing for stable and controllable expression in target cells. Researchers have used S100A8 adenoviral particles to study the role of this gene in inflammation, immune regulation, and disease mechanisms.