Human Raf-1 ORF clone(NM_002880.3)

Name: Human Raf-1 ORF clone(NM_002880.3)
SKU: CDCL185934
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL185934

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Product Information

Gene Information

Cat. No.	CDCL185934
Product Type	ORF clone
Gene Abbr	Raf-1
Species	Human
ORF Size	1947bp
Vector	pMD18-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

RAF-1

Background

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

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