Human RXRA adenoviral particles

The retinoid X receptor alpha (RXRA) gene encodes a nuclear receptor that plays a key role in regulating gene expression by binding to the retinoid X response element (RXRE) in target DNA sequences. As a member of the nuclear receptor superfamily, RXRA forms heterodimers with other receptors such as the retinoic acid receptor (RAR), vitamin D receptor (VDR), and thyroid hormone receptor (TR) to regulate a variety of physiological processes including lipid metabolism, cell differentiation, immune responses, and embryonic development. The ability of RXRA to interact with ligands such as 9-cis retinoic acid further highlights its importance in signaling pathways. RXRA dysregulation has been associated with metabolic disorders, cancer, and inflammatory diseases, making it a key target for biomedical research and therapeutic development.

Human RXRA adenoviral particles are genetically engineered viral vectors designed to efficiently deliver the RXRA gene into mammalian cells for overexpression studies. These particles leverage the high transduction efficiency and broad tropism of adenoviruses to enable stable gene expression in both dividing and non-dividing cells. The adenoviral system ensures rapid, high-level production of RXRA protein, making it ideal for functional assays, pathway analysis, and mechanistic studies. Researchers use these particles to study the role of RXRA in disease models, screen ligands or inhibitors, and explore its interactions with partner proteins.