Human PPP1CB adenoviral particles

The PPP1CB gene encodes the catalytic subunit of protein phosphatase 1 beta (PP1β), a key serine/threonine phosphatase involved in a variety of cellular processes including signal transduction, cell cycle regulation, and metabolism. As a member of the PP1 family, PP1β functions by dephosphorylating target proteins, thereby regulating their activity and ensuring cellular homeostasis. PPP1CB interacts with numerous regulatory subunits to form a holoenzyme with distinct substrate specificities, enabling it to participate in pathways such as glycogen metabolism, neuronal signaling, and muscle contraction. Dysregulation of PPP1CB has been implicated in diseases such as cancer, neurodegenerative disorders, and cardiovascular disease.

Human PPP1CB Adenoviral Particles are recombinant adenoviral vectors designed to deliver the PPP1CB gene to mammalian cells for overexpression studies. These particles take advantage of the high transduction efficiency and broad tropism of adenovirus, making them ideal for both dividing and non-dividing cells. The adenoviral backbone is designed to be replication-defective, ensuring biosafety while maintaining high transduction rates. Applications include exploring the role of PPP1CB in cell signaling, disease mechanisms, or potential gene therapy approaches.