Human POLE4 adenoviral particles

Name: Human POLE4 adenoviral particles
SKU: AD12564Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD12564Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD12564Z
Description	Adenovirus with ORF of polymerase (DNA-directed), epsilon 4 (p12 subunit) (POLE4).
Gene	POLE4
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit [ Homo sapiens ]
Gene Symbol	POLE4
Synonyms	p12; YHHQ1
Gene Description	polymerase (DNA-directed), epsilon 4 (p12 subunit)
GeneID	56655
Uni ProtID	Q9NR33
mRNA Refseq	NM_019896.2
Protein Refseq	NP_063949.2
Chromosome Location	2p12
Function	DNA-directed DNA polymerase activity; protein binding; protein heterodimerization activity; sequence-specific DNA binding;
Pathway	Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; DNA polymerase epsilon complex, organism-specific biosystem; DNA replication, organism-specific biosystem; DNA replication, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
MIM	607269

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