Human PDE9A Stable Cell Line-CHO-CNG-sGC

Name: Human PDE9A Stable Cell Line-CHO-CNG-sGC
SKU: CSC-RG1627
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG1627

Host Cell : CHO-CNG-sGC Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG1627
Description	This cell line is engineered to stably overexpress the human PDE9A in CHO-CNG-sGC cells.
Background	The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.
Target Gene	PDE9A
Gene Species	Homo sapiens (Human)
Host Cell	CHO-CNG-sGC
Host Cell Species	Cricetulus griseus (Chinese hamster)
Source	CHO-CNG-sGC
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Disease research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	PDE9A phosphodiesterase 9A [ Homo sapiens ]
Gene Symbol	PDE9A
Synonyms	HSPDE9A2
Gene Description	phosphodiesterase 9A
GeneID	5152
Uni ProtID	O76083
mRNA Refseq	NM_001001568.1
Protein Refseq	NP_001001568.1
Chromosome Location	21q22.3
Function	3,5-cyclic-GMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein binding;
Pathway	Hemostasis, organism-specific biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; cGMP effects, organism-specific biosystem;
MIM	602973

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